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BombeFR

THC ou CBC pour le cerveaux !!!

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BombeFR    8
BombeFR

Bonsoir a tous ,

 

d après les derniers études publier dans : THE JOURNAL OF NEUROSCIENCE

 

l article écrit :

  • Received September 8, 2015.
  • Revision received February 24, 2016.
  • Accepted February 25, 2016.

donc très ressent ,

 

Le plus actifs et réparateurs " séquençage électrique , stimulateur , régulateur " ,  aux niveaux du cerveaux serait, plus le Cannabidiol " CBD " , que ,  le Delta 9 Tétrahydrocannabinol " THC " .

Bien entendus l'un ne vas pas sans l autre ;)

 

Schizophrenia-related psychosis is associated with disturbances in mesolimbic dopamine (DA) transmission, characterized by hyperdopaminergic activity in the mesolimbic pathway. Currently, the only clinically effective treatment for schizophrenia involves the use of antipsychotic medications that block DA receptor transmission. However, these medications produce serious side effects leading to poor compliance and treatment outcomes. Emerging evidence points to the involvement of a specific phytochemical component of marijuana called cannabidiol (CBD), which possesses promising therapeutic properties for the treatment of schizophrenia-related psychoses. However, the neuronal and molecular mechanisms through which CBD may exert these effects are entirely unknown. We used amphetamine (AMPH)-induced sensitization and sensorimotor gating in rats, two preclinical procedures relevant to schizophrenia-related psychopathology, combined with in vivo single-unit neuronal electrophysiology recordings in the ventral tegmental area, and molecular analyses to characterize the actions of CBD directly in the nucleus accumbens shell (NASh), a brain region that is the current target of most effective antipsychotics. We demonstrate that Intra-NASh CBD attenuates AMPH-induced sensitization, both in terms of DAergic neuronal activity measured in the ventral tegmental area and psychotomimetic behavioral analyses. We further report that CBD controls downstream phosphorylation of the mTOR/p70S6 kinase signaling pathways directly within the NASh. Our findings demonstrate a novel mechanism for the putative antipsychotic-like properties of CBD in the mesolimbic circuitry. We identify the molecular signaling pathways through which CBD may functionally reduce schizophrenia-like neuropsychopathology.

SIGNIFICANCE STATEMENT The cannabis-derived phytochemical, cannabidiol (CBD), has been shown to have pharmacotherapeutic efficacy for the treatment of schizophrenia. However, the mechanisms by which CBD may produce antipsychotic effects are entirely unknown. Using preclinical behavioral procedures combined with molecular analyses and in vivo neuronal electrophysiology, our findings identify a functional role for the nucleus accumbens as a critical brain region whereby CBD can produce effects similar to antipsychotic medications by triggering molecular signaling pathways associated with the effects of classic antipsychotic medications. Specifically, we report that CBD can attenuate both behavioral and dopaminergic neuronal correlates of mesolimbic dopaminergic sensitization, via a direct interaction with mTOR/p70S6 kinase signaling within the mesolimbic pathway.

 

Copyright © 2016 the authors 0270-6474/16/365160-10$15.00/0

 

le sujets traiter de base étant la schizophrénie , sujets qui est en rapports avec beaucoup d autre pathologie du cerveaux, car du aux mauvais fonctionnements des récepteurs  " Synapses chimiques ou électriques " agissant ici sur la dopamine et donc aussi sur la sérotonine , sur soit , le contacts ou les micros transmissions électriques des différents Synapses et qui est aussi la cause de  " grave dépression ( sérotonine )" ou " de maladie mentale ( sérotonine ou dopamine ) " .

 

je pense que c est important pour nos malades de le savoir !!

 

Bonne soirée a tous  !!!

Modifié par BombeFR

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